Combination of Exercise and Intake of Amino Acid Mixture Synergistically Induces Beige Adipocyte Formation in Mice

Exercise combined with dietary factors may have significant effects on the suppression of body fat accumulation. Several trials suggest that amino acid mixtures containing alanine, arginine, and phenylalanine (ARF) exercise can significantly reduce accumulation in overweight adults high-fat diet-induced obesity mice. We therefore hypothesized combining ARF would induce beige adipocyte formation this contribute to reducing weight, whereas administration or alone not. Administration (1 g/kg daily) (5 sessions per week) for 4 wk induced adipocytes inguinal white adipose tissue (iWAT) mice, although did Metabolomic analysis showed plasma lactate concentration was elevated exercise+ARF group relative group. Furthermore, dehydrogenase B, which increases redox stress by converting pyruvate iWAT triggers induction uncoupling protein 1 expression upregulated These findings demonstrate unique effect inducing formation, be associated suggested lactate-mediated pathway. Appropriate acids could used as a supplement before contributed increasing energy expenditures.